Scientific Officer, Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China

Dr William Cho is a Chartered Scientist, a Registered Chinese Medicine Practitioner, Guest Professor of a number of Universities and a Fellow Member of several institutes, including the Institute of Biomedical Science (UK), Hong Kong Institute of Biomedical Science and Hong Kong Society for Molecular Diagnostic Sciences. Dr Cho has published over 300 peer-reviewed papers, e.g. Lancet Oncology, Nature Communications, Journal of Extracellular Vesicles, Clinical Cancer Research, Clinical Chemistry, Annals of Oncology, Theranostics; over dozen of books including "MicroRNAs in cancer translational research", "An omics perspective on cancer research", "Supportive cancer care with Chinese medicine", and over two dozens of book chapters. His current H-index is 42 with a total citations about 10,000 times.

Speech Title: Therapeutic resistance and recurrence of non-small cell lung cancer

Abstract: About 80% to 85% of lung cancers are non-small cell lung cancer (NSCLC), which is the leading cause of cancer-related death in the world. The identification of genomic alterations related to recurrence in NSCLC patients may help better stratify high-risk individuals and guide treatment strategies. While drug resistance is a major cause for therapeutic failure in NSCLC leading to tumor recurrence and disease progression, the personalized prediction of both therapeutic resistance and recurrence or metastatic disease progression still remains an unsolved problem. Our studies attempted to identify the molecular biomarkers of recurrence in NSCLC. Besides, we also tried to find the RNAs that play critical roles for tumorigenesis in lung adenocarcinoma.

In this presentation, I would like to share some researches on the identification of therapeutic resistance and recurrence by electroporation platform and next-generation sequencing technology, respectively. The studies on long non-coding RNA and circulating RNA will also be covered.

Keywords: Circulating RNA, circulating tumor cells, long non-coding RNA, next-generation sequencing, non-small cell lung cancer