School of life sciences, Jilin University, China

Pro. Di Wang graduated from The University of HongKong in 2013, and worked at Jilin University at the same year. He focus his research on the function screening and mechanism investigation of mushroom and the compound prescriptions of TCM. Till now, Pro. Wang has undertaken 16 projects including National Natural Science Foundation of China, Key Scientific and Technological Project in Jilin Province and Industry-University-Research Cooperation Projects. Accumulative scientific research funds reach to RMB 8.5 million. Pro. Wang has published over 100 SCI indexed papers as the first responsibility author, and obtained 8 authorized national patents.

Speech Title: Investigation on the Pharmacological Efficacy of Endemic Mushrooms and underlying mechanisms in Changbai Mountain Area

Abstract: According to the statistical data, there are 1789 edible and 798 medicinal fungi in China. In Changbai Mountain area of Jilin province in China, there are still unrevealed mushrooms. We focused our research on the pharmacological functions of edible and/or medicinal mushrooms and their effective constituents. Till now, we successfully developed over 30 types of mouse and/or rat models for evaluation the effects of agents on 13 kinds of diseases, such as depression, diabetes, osteoporosis, alcohol-induced liver injury, Alzheimer’s Disease, colitis and colon cancer, and et al. Based on these animal models and related cell models, we have detected the functions of over 19 types of mushrooms, and their constituents including polysaccharides, triterpene, alkaloid and flavone. By combining the proteomics, metabonomics, western blot, and ELISA, we further investigated the mechanisms of the revealed functions, most of which were focused on the modulation of oxidative stress system. Encouragingly, based on our research results, four functional food contained different mushrooms with the effects on renal protection, anti-diabetes and anti-fatigue have got into declaring stage in China.

Key Words: Mushrooms, Pharmacological Efficacy, Changbai Mountain Area, Pharmacological mechanisms